چکيده
In summary, an injectable MOF-based hydrogel loaded with DOX (HA-BP ·MOF@DOX) was developed for cancer treatment based on the concept of local sustained drug release at the tumor site. The cross-linkages of the HA-BP ·MOF@DOX hydrogel were formed by coordination bonds between the BP groups in HA backbones and Zn 2+ ions on the MOF. The inherent dynamic characteristics of BP-metal ion interactions generated the dynamic networks of the hydrogel with self-healing, shear-thinning, and smooth in-jectableproperties. The MOF particles served as both drug encap-sulationplatform and hydrogel network cross-linking points. The HA-BP ·MOF@DOX hydrogel showed stimuli-responsive drug release ability following a decrease in pH and ATP addition, wherein the drug could be controllably released. Compared to the MOF@DOX treatment group, the HA-BP ·MOF@DOX hydrogel demonstrated en-hancedanticancer efficacy in vivo . Mice experiments and histo-logical results revealed good biocompatibility of HA-BP ·MOF@DOX in vivo . Thus, the developed dynamic MOF-based hydrogel is a promising and practical injectable localized drug delivery system for anticancer treatment.
