چكيده به لاتين
Metal-organic frameworks (MOFs) are highly functional in the field of catalytic, separation, sensing and more recently in pharmaceutical applications. Achieving a stable and nontoxic framework with high drug loading capacity without losing of crystalline structure is an interesting challenge. As a pioneer work, this study represents a method for simple synthesis of a stable and nontoxic metal-organic framework based on iron ions, drug molecules and organic ligands as linkers, for drug delivery applications. Also we investigate the potencial of Zeolitic imidazolate frameworks (ZIFs) and MIL-100-Fe for the controlled release of model drug. Herein, Metformin (Met) (Scheme 1); an oral antihyperglycemic agent for the treatment of type II diabete was utilized as a model drug. Here metformin as an organic sub-linker, was combined with trimesic acid (1,3,5 benzene tricarboxylic acid) through hydrogen bonds in a short and simple way to affording a MOF structure. In order to make this drug delivery systems stable and smart, sodium alginate, a biodegradable, accessible and pH sensitive natural polymer was applied to coat the MOFs surfaces. Sodium alginate acts as a complexing agent and attached to Lewis acid sites on the nanoparticle surface through its hydroxyl and carboxylate groups, with no negative effect on drug release from the frameworks. This approach leads to targeted release of metformin, thereby decrease the potential of side effects, and increase its bioavailability. Furthermore it should be theoretically possible that this new synthesis method is capable to be extending to other drugs, especially anti-cancer drugs.
