چكيده به لاتين
So far many studies have been conducted on bone filler that majority of them are based on using of Poly(methyl methacrylate) (PMMA). Usage of PMMA can cause plenty of problems, in order to, researchers trying to find substitutional materials. The studies showed that usage of composites that based on Poly(propylene fumarate) (PPF) are able to reduce PMMA problems. The aim of this study is to improve biological and mechanical properties of PPF by using Micro and Nanoparticles as reinforcements of Magnesium Calcium Phosphate (MCP). This research includes three stages. At first, Functional group, structure and molecular weight of the synthesized PPF was characterized by FT-IR, H-NMR, and GPC. Then, according to the results of compressive tests, the optimum amount of crosslinker, free radical initiator, and accelerator of polymerization factors was determined. At the second step, the MCP Micro ceramic was synthesized by using of emulsion method and in the following, MCP Nano ceramic was produced by fast milling with planetary mill. The structure and morphology of synthesized Micro and Nanoceramics were investigated with XRD and SEM. In order to precise measurement of Nano particle’s size, the Dynamic light scattering was employed. At the final stage, due to results of compressive tests on PPF/MCP Micro and Nanocomposites, the optimum amount of Nano and Microparticles addition to polymeric matrix, was determined as 10 wt%. The biological assessments showed that bone-like Hydroxyapatite was formed on Nano and Micro-composites. Also, PPF/MCP composite did not have a toxic effect on growth and cell proliferation, even growth and proliferation was promoted. Therefore, according to mechanical properties, bone tissue forming and proper reaction with osteoblast cells, PPF/MCP composites can be assumed as an appropriate choice for bone tissue reconstruction.
