چكيده به لاتين
Generally, the drug is absorbed through the gastrointestinal tract, such as pills and non-digestive organs, such as infusion. In these methods, problems such as the formation of drug concentrations in the blood, pain, bleeding, inflammation due to injection and problems associated with taking pills Abrupt release of the drug, causing toxicity, and stimulating the stomach. Therefore, a trans dermal drug delivery can slowly and slowly release the drug, which is very important. Unfortunately, due to the presence of stratum corneum on the skin, less than 10 drugs can be used in the above manner. One of the best ways to overcome the stratum corneum is to use a microneedle for the delivery of a variety of drugs, such as peptide and macro molecular drugs. Microneedle is an array of needles that, by creating reversible micro channels in the skin, with minimal pain and damage, allows the passage of drugs, such as macro molecules, vaccines and hormones from the skin. The purpose of this project is to familiarize with the types of micro dermabrases, their application in the macro molecular drug delivery, and to study the microneedle manufacturing methods. In this project, the micro drive was developed using laser, lithography, etching, milling and some innovative and simple methods. In comparison with the methods, milling was introduced as an optimal method. Milling is a machining method that is pre-written on the device by means of tools for implementing the plan given by the G code programming. At the end of this project, by examining the final mold of the mold making, designed in this project, is evaluated by external testing. The images obtained from Microneedle show how to design and formulate micro graphs correctly in the mold design.
