چكيده به لاتين
Tissue engineering as a promising method for curing illnesses and defects, has been received a great attention from researchers. This process initiate with fabrication of a biocompatible scaffold. One of the most significant aspects of the fabricated scaffolds is its mechanical properties.
In this thesis we focus on evaluating the mechanical properties of porcine gelatin and cellulose acetate electrospun nanofibers. For this reason, we first fabricated the nanofibers, considering several process parameters effecting the scaffold properties. Next step is measuring the mechanical properties; Elastic modulus, Yield stress and Strain at rupture, and deriving the relation between inlet parameters and mechanical properties. To make this happen, we employed response surface method in order to regress the experimental data. Verification of our model was approved by studying the errors of all 3 model applied to define different mechanical proeprties of fabricated scaffolds.
With solution concentration, polymers weight ratio and mandrel rotation speed as input variables, and elastic modulus, yield stress and strain at rupture as output variables, we draw output contours and define the impact of each input variables on mechanical properties. Understanding the interaction between process parameters of electrospinning method could contribute the engineers to adjust them so as to get achieve desired mechanical properties of scaffolds.
