چكيده به لاتين
From the studies in the field of drug delivery, it has been deduced that one of the most important challenges which pharmaceutics has been faced in these days are the lack of ability to produce drug carriers with suitable precision and controllability over the specific number of drug carriers. Hence, engineers, with the help of Science, are looking for the solution. The production of pharmaceutical particles based on microfluidic devices has been considered as an adaptive device with a wide range of applications which the most important of them are as follow: the small volume of reagent consumed, the massive production of uniform particles, high surface area to volume ratio that facilitates fast reaction, and suitable release controllability.
In this research, first of all some of the drug carriers will be introduced after that the wide range of geometries which has been used in droplet generation with the aid of microfluidic devices will be presented. Then two types of common geometries are proposed for the production of droplets. Subsequently, the effect of geometrical and mechanical properties and fluid parameters on the diameter of the generated droplets are being evaluated. In general, three types of devices which are based on microchannel and capillary tube has been designed and constructed in this study.
On the other hand, the fluid movement in two types of devices is passive and in the other is active. It should be noted that according to the results obtained, by increasing the viscosity ratio to surface tension, the diameter of the channels and the ratio of the flow rate of the two fluids, which indicate the characteristics of the fluid, the geometric and kinematic parameters, the diameter Particles have decreased, respectively. The diameter of the produced particles has been reported in experiments ranging from 50 to 2000 μm with a deviation coefficient of less than 5%.
