چكيده به لاتين
Abstract:
The atomic force microscope is a powerful and multifunctional device in the field of imaging that provides the observation and manipulation of biological samples, including single cells, in biological and non-biological environments. But due to the impossibility of simultaneous transfer and imaging of particles, by modeling and considering all the parameters in the laboratory, including particle morphology, cell placement and other factors can bring the results closer to reality. In addition, in order to control the path of motion of the particle in different applications, such as drug delivery and tissue engineering, particle motion can be routed using software.
In this study, topography of benign breast cancer cells will be performed using an atomic force microscope in a fluid medium and in a contact mode. By processing the images in the software, the cell surface roughness coefficient and the particle roughness will be extracted. Then, by applying the folding factor in elastic and viscoelastic contact models Hertz, DMT and JKR, these modalities will be corrected and the results indicate that the application of this coefficient in the contact models will bring the results closer to the experimental data that was obtained from the topography. Also, in this study, the Hamaker constant will be modified in viscoelastic mode and by applying the folding factor and cooper roughness model in elastic and viscoelastic three-dimensional manipulation in both air and liquid media, the effect of these factors on the critical force and time of the manipulation of the particle in the first phase and the procedure of the changes in the manipulation force in the second phase will be studied. In addition, using genetic algorithm and designing an environment with random static obstacles and taking into account different constraints, the optimal path of the particle motion will be determined.
Keywords: Folding factor, Contact models, Roughness of viscoelastic models, Three dimentional manipulation, Path planing
