چكيده به لاتين
Medical treatments using laser irradiation have attracted increasing attention in recent years. Some reports said low energy laser irradiation can block the conduction of nerve impulses or can improve recovery from nerve injuries. These effects can be helpful in diagnose and treatment of diseases caused by propagation in nerve, such as Parkinson and eppilepcy. In addition, optical stimulation in compared to common treatment method, electrical stimulation, has significant advantages. Optical stimulation is noninvasive, presice and has ability of spatially selectivity. It also does not produce stimulation artifact. The benefits of optical stimulation are very much taken into account, so that in the last ten years, a new field in bioelectric engineering has been proposed as optogenetic. Nowadays this method has many application in brain control technology, and nervous diseases treatment. Due to the importance of light effects on cells and its propagation along nerve, in this research low power laser effects on propagation in nerve has been investigated. Althought main approach in this study was theoretical and insilico simulation, experimental studies were conducted. The experiences gained from these studies can be used in future projects. Then, using the electrophysiological knowledge obtained from the authoritative references, the propagation of action potential in the nrve under low-power laser is simulated. For this purpose, laser effects was considered by two approaches; effect on ionic conductunces and membrane electrical capacity. To validate the results, using experimental data, combined stimulation modality was simulated. The results are largely in line with experimental data.
