چكيده به لاتين
Iron oxide nanoparticles (including Fe2O3 and Fe3O4) have been widely used in biomedical applications such as hyperthermia, especially for the treatment of cancer, controlled release, and targeted drug delivery. In this study, magnetite nanoparticles were synthesized by co-precipitation method. Then, a layer of porous silica coated magnetite nanoparticles for loading the drug. The MNP @ mSiO2 @ PCBMA nanogels were then prepared using inverse microemulsion. The goals of this research, Synthesis of MNP @ mSiO2 @ PCBMA Nanogels for controlling drug release and Preventing the removal of nanoparticles by the reticulovantothelial system (RES) by reducing the interaction of nanoparticles with proteins corona, because corona proteins cause the drug delivery system to fail. Synthesized nanogels have the capability to transport the drug and use as a contrast agent at the same time. The resulting nanogels are very stable and easily portable. To evaluate the system, its release profile of tamoxifen anticancer drug (TMX) was studied because it has not yet been evaluated on the porous silica system. The average size of mesopores is about 3/67 nm based on BJH calculations. Drug release from nanogels at pH 7.4 ,T=37℃ , pH 7.4 ,T=42℃ , pH 6.7 ,T=37℃ and pH 6.7 ,T=42℃ are 13/4, 30/45,24/4 and 45/23 respectively. The results show that the nanogels prevented the burst effect of drug. The magnetization of OA-MNP, OA-MNP @ mSiO2 and OA-MNP @ mSiO2 @ pCBMA nanoparticles are 56/17, 34/55 and 15/58, respectively. The biocompatibility of the nanogels was determined by MTT assay, which results in cell growth and proliferation after 72 hours. Analysis used in this study include SEM, TEM, FTIR, VSM, BET, TGA, MTT, NMR, UV-VIS spectroscopy and XRD.
