چكيده به لاتين
In recent years, the use of calcium phosphate biomaterials, especially hydroxyapatite, has been considered due to its similarity to bone mineral content and its high biocompatibility. Some efforts have been being channeled on overcoming problems associated with these ceramics to improve their biological and chemical properties. Cobalt is an essential element for the appropriate functioning of the body and iron is also a vital element that is available in bones. Iron has an array of usages in medical fields such as drug release, imaging, etc.
According to reasons mentioned, iron- and cobalt-doped hydroxyapatite nanoparticles were synthesized using nitrate salts of calcium, iron, and cobalt and ammonium hydrogen phosphate based on the hydrothermal method. In this research, the effect of the different molar ratios of substitutional ions on biomaterial features was appraised. The physicochemical and magnetic properties of the nanoparticles were evaluated using XRD, FTIR, FESEM, ICP, and VSM. Submersion in SBF for 7 days and MTT test were used for biological and bioactivity assessment. The antibacterial activity of the samples was also estimated by the disk diffusion method. The results confirm: (1) the calcium ion substitution of the hydroxyapatite structure by iron and cobalt ions, (2) the nanometer dimensions of the samples, and (3) change of magnetic behavior from diamagnetic to paramagnetic. Bioactivity, biocompatibility, and antibacterial properties of samples were approved. Based on their characteristics, these materials could find a great position in osteosarcoma treatment.
