چكيده به لاتين
Cancer therapy with hyperthermia approach is a kind of medical treatment in which tissue is exposed to high temperatures in order to damage and kill cancer cells or to sensitize cancerous cells to the radiation and chemotherapy.
There are several methods that can be used in cancer treatment such as resistive heating, microwave heating, radiofrequency, T-rays, ultrasound, magnetic nanoparticles and so on. This thesis is about hyperthermia using magnetic nanoparticles is the suspension fluid.
This is the newest method is based on the fact that if the magnetic nanoparticles expose under the influence of a magnetic field, heating will have produced in cancer tissue. As a result, if the magnetic nanoparticles inject into a cancerous tissue within an alternating magnetic field with high amplitude and frequency, tumor tissue temperature will increase. This increase causes the destruction of cancer cells.
Numerous studies have been made about the created heating which are most conducted on the dead tissue that due to the loss of capillary blood flow has a significant difference with living tissue, or on a small number of mice alive tissue which is very costly and non-generalizable. The purpose of this thesis presents a new method to simulate the interrupted blood flow in kidney tissue of the living creature (sheep).
In this thesis by synthetic reperfusion similar to natural state in the kidney of a recently slaughtered sheep, the conditions for a thorough review of tissue in the process of hyperthermia by using super paramagnetic nanoparticles was provided. Also hardware for producing an alternating magnetic field and tempreture measurement is made and finally, by testing and simulating the process in fininte element software, the kidney tissue heating condition is evaluated.
