چكيده به لاتين
Particle synthesis using microfluidic methods, by providing the possibility of precise control of parameters related to the synthesis process, achieves particles with uniform and controlled size. In this dissertation, polycaprolactone (PCL) nanoparticles were synthesized using microfluidic method. For this purpose, two different geometries were studied. In the first geometry, a glass capillary device was designed and fabricated and the desired microchip was used to synthesize PCL nanoparticles. The second geometry was a silicon-pyrex device with two angled inputs for continuous phase and one divergence angle at the microchannel output. The simulation of this geometry was compared with the experimental studies of the reference paper. Then, by using microchip, the desired polymeric particles were produced and in terms of shape, size distribution and stability of the chemical composition were investigated. Also in this dissertation, hydrodynamic simulation of PCL nanoparticle production was performed using COMSOL 5.4 Multiphysics software with the geometry intended for this purpose. As it is known, by changing parameters such as the concentration of continuous and dispersed phases as well as changing the velocity of the phases, the resulting particle size can be changed and controlled. Then, the steps of nanoparticle formation, determination of flow regime and the mass transfer mechanism of the produced droplets in the microchannel was investigated and in the same way, the mass transfer rate and solidification time were calculated. It was observed that by extracting the solvent from the dispersed phase to the continuous phase, the mass transfer rate increases. Also, the diameter of the produced nanoparticles was estimated using correlation, hydrodynamic methods and image processing. Finally, The results of microchannel simulations were compared with experimental studies. Also In this research, it was proved that polymeric nanoparticles of PCL with very desirable properties can be obtained by using high pressure microfluidics.
