چكيده به لاتين
Additive manufacturing (AM) which is commonly referred to 3D printing, has gained great attention in recent years as it allows the creation of complex 3D geometries with precisely prescribed microarchitectures, which is necessary in Biofabrication and biomedical studies.
Here, we report a method to prepare UV-curable hydrogel based on GelMA with TPO nanoparticles as photoinitiator. After synthesis and characterization of GelMA and TPO nanoparticles, a bio-resin was prepared and printed via lithography-based DLP 3D printer. It was demonstrated that TPO nanoparticles, which was insoluble in water in bulk form, worked correctly in DLP printer. The TPO nanoparticles were prepared by rapid conversion of volatile microemulsions into water-dispersible powder, a process that can be used for a variety of photoinitiators. For biocompatibility studies, HUVECs were cultured on fabricated scaffold. Increase in viability of cultured cells in 24h, 48h and 1 week after culturing, showed that this bioresin is capable of modeling tissue for drug screening and disease modeling.
