چكيده به لاتين
Today, for the importance of health and prevention of disease progression, targeted drug delivery has been proposed to cause the highest efficiency of drug delivery. Among the targeted drug delivery methods, use of ultrasound waves and then placing microbubbles as drug carriers in the acoustic field. In this research, numerical simulation of these particles in an acoustic field has been performed using Comsol software. First, while studying previous research and the results, we try to resolve and answer one of the existing gaps. Then, the microbubble with a gas core with a radius of 2 μm and a phospholipid shell with a thickness of 10 nm, was placed in the simulation environment and affected by the acoustic field. Considering the three variables of acoustic pressure coefficient, viscosity, and excitation frequency, The results were examined. Since in the previous studies, the studied particles were mostly solid, in this study, the results for these particles were repeated and compared with the output of microbubbles. The outputs of the simulation were obtained in the form of four graphs of displacement, velocity, drag force, and total force applied to them, and the effect of changing each of the three variables of viscosity, frequency, and acoustic pressure coefficient on the four graphs is mentioned. Charts often oscillate around acoustic pressure and eventually dampen toward their oscillation axis. Also, it has been observed that the behavior of these two particles in different sizes is very different from each other, and this proves the need for further studies and research on microbubbles. More knowledge of them will lead to widespread use in health discussions.
