چكيده به لاتين
In recent years, stimulus-sensitive hydrogels have attracted much attention due to their potential in a wide variety of applications, especially in the fields of biomedicine and biotechnology. For these applications, when designing the overall system, it is important to understand the deformation kinetics and equilibrium swelling of the hydrogels. Since the sensitivity and release of hydrogels in drug delivery has been identified, it has increased interest in their use in the field of drugs. Therefore, it requires a complete understanding of the characteristics of hydrogels in response to environmental conditions such as pH, temperature, light, concentration, sound, wave, and so on. This research deals with the phenomena of transfer and deformation of stimulus-sensitive hydrogels with one main goal; which includes the study of fundamental physics, chemistry of stimulus-sensitive hydrogels and the swelling process. The response of a hydrogel can be explained by various physical equations by balancing mass, charge, energy and force by creating an osmotic pressure in the hydrogel that causes it to swell / contract. In this research, a mathematical model consisting of Nernst-Planck, Poisson, Heat and force balance equations for combining ions and drugs with deformation of hydrogels under osmotic pressure is presented. Swelling simulation in steady-state conditions is performed separately and simultaneously with emphasis on pH and temperature response. In this way, the effect of temperature and pH stimuli on the hydrogel is related to the osmotic pressure resulting from the mixing and diffusion of ions, respectively; The former are based on the molecular thermodynamic model and the latter are based on the electro-chemical-mechanical model. For simulation, COMSOL finite element software was used and for validation, experimental data from other sources were used. In this study, swelling of hydroxyethyl methacrylate (HEMA) hydrogel in range of 0-40 C and pH 2-11 have been examined in separate and integrated cases; Similarly, the effect of the parameters used in the models is studied and the results are compared with the published experimental data. The simulation results show that the results of the mathematical model are in good agreement with the experimental results expressed in the references..
