چكيده به لاتين
Surgical infections are a major problem cause of implant failure. To solve this issue, scientists have used silver, copper, cobalt, etc. as antibacterial agents in hydroxyapatite phase. In this research, for developing antibacterial and bioactive properties, we have doped Ag-Cu and Ag-Co simultaneously in HA. Therefore, Ca10-x-y Ag x Cu y (PO4)6 (OH)2 and Ca10-x-y Ag x Coy(PO4)6 (OH)2 with value ( x, y= 0.5 M ) and Ca10-x Ag x (PO4)6 (OH)2 , Ca10-x Cu x (PO4)6 (OH)2 and Ca10-x Co x (PO4 )6 (OH)2 composites ( x= 1 M ) were synthesized . Co-precipitation is a simple and low cost method, which has used in this process. Structural properties of samples have characterized by XRD, FTIR and FESEM analysis. The result of XRD and FTIR analysis revealed pure HA phase with no minor other phase and dopants ions displaced to Ca sites well. Spherical morphology was appeared in all samples by FESEM test however the size of particles decreased by inserting dopants. Moreover, VSM test used to determine magnetic characteristic in HA-Co and HA-0.5(Ag-Co) materials so, it shows more Ms and Mr in samples with Co doped HA. Two E. coli and S. aureus bacteria used to evaluate antibacterial property. However, this antibacterial characteristic observed in all doped samples but the results of HA-0.5(Ag-Cu) and HA-0.5(Ag-Co) indicate the most effect against bacteria. Bioactive tests evaluated by immersion pressed samples in simulated body fluid for 7 and 21 day. FESEM analysis, pH changes, gaining weight and ICP_OES test utilized after immersion in SBF for all samples. The results show more bioactive properties in HA-0.5(Ag-Cu) and HA-0.5(Ag-Co) materials compared to other materials.
