چكيده به لاتين
Microfluidics is the study of systems that can process small quantities of fluids by using tiny channels having dimensions at the microscale typically tens to hundreds of micrometers. This technology has been considered due to increased sensitivity, accuracy, speed, ease, and reduction of manufacturing costs. To make a microfluidic chip, we need components such as micro-valves and micro-channels. Microvalves are fundamental components of many microfluidic systems. Microvalves control routing, timing, and separation of fluids within a microfluidic device and are crucial for designs with complex functionality. Using microvalves, temporal sequences of fluids can be programmed to produce combinatorial mixtures and gradients, droplet combinations, nucleic acid manipulations, and cell culture conditions. Additionally, microvalves allow for tuning of flow resistance and microchannel topography at a spatiotemporal scale that is inaccessible to manual manipulation. Microfluidic automation spares the costs of human labor and enables faster processing through miniaturization and parallelization. In this study, Check valves were designed with Comsol software and the rate of rectification, pressure drop, and velocity drop were investigated and compared. According to the results, the highest amount of diodicity belonged to the diffuser nozzle valve of the second-type design, nozzle valve, cogwheel, Tesla, and other types of diffuser nozzle valves, respectively. The chip was made by two methods, the first method was to create a PMMA mold by laser cutting and casting liquid PDMS and then to bake it, the second method was to engrave on glass by laser cutting method and design a microvalve with PMMA. In this project, several samples of microvalve have been made.
