مريم سلگي

One of the challenges that medical science has faced over time is to provide a solution to treat the body's damaged tissues. The main goal of tissue engineering is the development of biological alternatives in order to regenerate, maintain or improve damaged tissue and organ function. Designing and manufacturing scaffolds with optimal properties are critical for success in tissue engineering. Several methods have been developed to fabricate two and three-dimensional scaffolds. Conventional methods have limitations for producing scaffolds with specific micro-architectures in terms of porosity, pore size, geometry, and interconnectivity. Additive manufacturing techniques or 3D printing have appeared as a solution to the drawbacks of conventional manufacturing methods. The research aims to fabricate and characterize a polymeric scaffold made of Polycaprolactone (PCL)/ Amine-terminated polyethylene glycol (PEG-NH2) by 3D printing. The scaffolds were examined using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), contact angle measurement, biodegradability, and water absorption. The thermal properties of the scaffolds were investigated using differential scanning calorimetry (DSC). Furthermore, the mechanical properties of the resulting scaffolds were studied by tensile and compressive strength tests. Biological properties were studied by cell adhesion, Hemocompatibility, platelet adhesion, and MTT assay. The results of FTIR analysis confirmed the presence of PEG-NH2 in the composite structure. The results of contact angle and water absorption indicated an increase in the hydrophilicity of composite scaffolds compared to pure PCL scaffolds. Furthermore, the mechanical properties tests revealed that composite scaffolds had higher tensile and compressive strength than pure PCL scaffolds. The results of biological eva‎luations indicated that developed scaffolds are Hemocompatible, non-toxic, and biocompatible. Thus, the fabricated composite scaffolds can be a good option for cardiac stents.

مهندسي بافت , پرينت سه بعدي , داربست , پلي كاپرولاكتون , پلي اتيلن گليكول با انتهاي آميني , استنت قلبي

Tissue engineering , Three-dimensional printing , Scaffold , Polycaprolactone , Amine-terminated polyethylene glycol , Cardiac Stent

maryam solgi

Dr. Alireza Khavandi Dr. Ali Zamanian