Fabrication of polymer wound dressing reinforced with graphene, selenium nanoparticles and plant extracts and eva‎luation of its antibacterial properties

10/22/2023 12:00:00 AM

Today, the expansion of science and increasing attention to health has become a factor to make wound dressings more advanced and provide standards for a good wound dressing that, in addition to antibacterial properties, create high porosity to ensure the proper entry of oxygen into the wound. One of the new methods of quick recovery and repair of wounds is the use of polymer nanofibers to produce wound dressings. In this project, the production of polyurethane polymer wound dressings and its reinforcement with graphene oxide, henna extract, selenium nanoparticles and their combination by electrospinning method have been discussed and then the morphological and antibacterial properties and mechanical properties have been investigated. In this regard, in the first stage, by optimizing the parameters of electrospinning, the production of polymeric wound dressing and its reinforcement has been done, and in the second stage, the properties of the produced wound dressings have been investigated. The structure and morphology of the wound dressings were examined using scanning electron microscope test and based on the results, adding graphene oxide and henna extract creates high porosity for the entry of oxygen inside the wound in the polymeric wound dressing. to be The antibacterial properties of the wound dressings produced against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli were investigated based on standard 10900 and the antibacterial activity of wound dressings reinforced with graphene oxide against Gram-positive and Gram-negative bacteria was 0.1 and 0.29, wound dressing reinforced with henna extract 2.3 and 2.5, wound dressing reinforced with selenium nanoparticles 2.51 and 2.57 and for the combined sample 2.9 and 2.94. The mechanical properties of the produced wound dressings were investigated using a tensile test, and the amount of tension and strain at the UTS point in the unreinforced wound dressing was equal to 45 Mpa and 395%, the wound dressing reinforced with graphene oxide was 50 Mpa and 311%, the wound dressing Reinforced with henna extract 25 Mpa and 257%, wound dressing reinforced with selenium nanoparticle 73 Mpa and 286% and for the combined sample 92 Mpa and 120%.

زخم پوش , نانو كامپوزيت پايه پليمري , الكتروريسي , گرافن , خواص ضد باكتريايي

wound dressing , polymer-based nanocomposite , Electrospinning , Graphene , antibacterial properties

Shahab Sepanloo

Dr. Meisam Jalali