چكيده به لاتين
Cancer is one of the biggest health problems in the world and it kills millions of people worldwide every year. Currently, the common methods of cancer treatment are associated with complications and limitations. In recent decades, hyperthermia has been considered for cancer treatment, and with the advancement of nanotechnology, magnetic nanoparticles are used for the targeted transfer and distribution of heat. In this method, after the injection of nanoparticles into the tumor, heat is generated by applying an alternating magnetic field. Experiments have been conducted to check the heating ability of nanoparticles, but more extensive studies are still needed. Computer modeling and simulations are used to solve some of these problems. The success rate of this treatment method depends on the magnitude and distribution of the final temperature. Therefore, in this study, it has tried to achieve the optimal temperature distribution by choosing the appropriate model and parameters, and at least 90% of the tumor is placed in the temperature range of 40 to 50 °C.
In this study, the governing equations of the problem were determined first, and then the treatment process was simulated with the help of computer modeling. The results show that among the investigated parameters, the effect of the nanoparticles' diameter, the frequency and the amplitude of the applied magnetic field is the most important. Also, the results obtained from the model validation indicate the desired accuracy of the performed simulation, so the error rate between the results of this research and the reference article is about 3.16%.
Finally, from this research, it can be concluded that in the process of hyperthermia treatment, by changing parameters such as the diameter of nanoparticles, the amplitude and frequency of the magnetic field, as well as the magnetic anisotropy constant of nanoparticles and some other parameters, it is possible to reach the desired treatment temperature range.
