كوثر جلوه قاضياني

Magneto-photothermal therapy is considered one of the effective approaches in cancer treatment, combining photothermal therapy and magnetic hyperthermia. Magneto-plasmonic nanomaterials consist of magnetic nanoparticles with plasmonic or metallic shells, commonly known as magneto-plasmonic agents. These agents are simultaneously exposed to infrared laser radiation and a variable magnetic field. This thesis initially focuses on studying the optical properties of gold-coated nanostructures, which include various magnetic core materials with a graphene coating, using the Mie theory and effective medium theory. Subsequently, by solving the bioheat equations, the temperature distribution resulting from the interaction of magneto-plasmonic nanoparticles with laser irradiation and a variable magnetic field is calculated in three-dimensional tumor tissue and its surrounding environment. The thermal dissipation efficiency of the nanoparticles in the tumor tissue demonstrates that the surface plasmon resonance peak can be finely adjusted within a wide range of biological windows by altering the internal magnetic core radius, gold shell thickness, and graphene coating. Additionally, the influence of the number of graphene layers and laser intensity on temperature elevation is eva‎luated. To assess treatment effectiveness, the probability of thermal damage in the tumor tissue is quantified using the Arrhenius equation, and irreversibly damaged regions are identified. Furthermore, the thermal density distribution within the nanoparticle is determined by analyzing the distribution of electric field intensity surrounding it. Finally, this thesis examines the temperature changes induced by the simultaneous presence of a variable magnetic field and laser irradiation. The results demonstrate that magneto-plasmonic nanoparticles with graphene coating can serve as highly efficient and thermally stable nanocarriers for cancer treatment, employing the magneto-photothermal therapy approach.

مگنتو - فوتوترمياتراپي , مگنتوپلاسمونيك

Magneto-photothermal therapy , Magneto-plasmonic

Kosar Jelve Ghaziyani

Mehdi Esmaeilzade