سيده ندا حسيني

Today, the development of science and increasing attention to healthcare has become a factor to make wound dressings more advanced and provide gold standards for a good wound dressing. Antibacterial, analgesic, biocompatible properties, the ability to carry medicine, flexibility and the ability to absorb secretions in the wound. One of the new methods of quick recovery and repair of wounds is the use of hydrogels to produce wound dressings. In this project, the fabrication of hydrogel-based wound dressings and reinforcing it with the extract of Scrophularia striata plant and graphene oxide nanoparticles has been investigated in the field of acute burn wound treatment. In this regard, in the first step, by optimizing the parameters, hydrogel-based wound dressing has been fabricated and augmented. The optimal sample with a combination of chitosan/guargam/polycaprolactone/Scrophularia striata plant extract and graphene oxide with the amount of 0.5 (g), 0.5 (g), 0.8 (g), 5 (ml) and 50 (µl) was prepared. In the second stage, the properties of the produced wound dressings were examined. The amount of hydrophilicity of wound dressings was assessed, and the optimum hydrogel sample and the sample containing the extract of the Scrophularia striata plant increased the amount of surface hydrophilicity, which had a contact angle of 57.7 and 61.2 degrees, respectively. The results of the swelling test showed that the sample containing graphene oxide has the ability to absorb more water due to its honeycomb structure. The higher this percentage is, the higher the water absorption ability will become. The antibacterial properties of the wound dressings examined against the gram-positive bacteria Staphylococcus aureus and the gram-negative bacteria Escherichia coli. The optimal samples showed 2.3 and 2.2 (cm) diameter of inhibitory. Finally, the results of cell analysis were eva‎luated for 168 hours, and the results of 24 and 72 hours had no toxicity, as well as enhanced cell growth.

هيدروژل , گياه تشنه‌داري , گرافن اكسايد , كيتوسان , زخم‌پوش

hydrogel , Scrophularia striata , graphen oxide , Chitosan , Wound Dressing

Neda Hosseini

Dr. Meisam Jalali