سعيده سعيدي

In recent years, there has been a great interest in finding new molecules with environmental effects for Alzheimer's disease (AD). selective loss of cholinergic neurons in AD leads to a lack of acetylcholine (Ach) in certain areas of the brain that mediate learning and memory functions. Therefore, the primary approach to AD treatment is focused on increasing the level of acetylcholine, and this has made acetylcholinesterase (AChE) inhibitors to be considered a suitable therapeutic target for the treatment of AD and the cause of dementia. Therefore, the development of new and effective methods for the synthesis of 1,2,3-functionalized triazoles and functionalized quinolines is significant. In organic chemistry, these synthetic compounds have a wide range of biological properties such as antibacterial, antifungal, antiviral, etc. In this research, the hybridized derivatives of mercapto-formyl-quinoline to 1,2,3-triazole-acetamides were investigated and synthesized by using click chemistry and using Cu@EDTAD-PMO supramolecular nanocatalyst. In it, ethylenediaminetetraacetic acid (EDTA) as a bridging ligand was eva‎luated as a potential anti-Alzheimer drug. The structure of derivatives was confirmed using 1H NMR and 13C NMR spectroscopy results. Also, their binding affinity with AD therapeutic targets (AChE and BChE) was investigated using molecular docking (MD), these structures had a high affinity with the catalytic sites of the corresponding enzymes.

Alzheimer's disease, acetylcholinesterase inhibitor (AChEI), butyrylcholinesterase inhibitor (BChEI), 1,2,3-triazole, quinoline, acetamide, supramolecular nanocatalyst, Periodic Mesoporous Organic Silicas (PMOs). .

بيماري آلزايمر، مهاركننده¬¬ استيل¬كولين¬استراز(AChEI)، مهاركننده بوتيريل¬كولين استراز (BChEI)، 3،2،1-تري¬آزول، كينولين، استاميد، نانوكاتاليست فرامولكولي، سيليكاهاي آلي مزومتخلخل دوره¬اي (PMOs).

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