چكيده به لاتين
In light of rapid advancements in medicinal compound separation, drug delivery, and pharmaceuticals, there is an increasing need for new, environmentally friendly, simple, and economical techniques. One such efficient method that shows promise is the use of aqueous two-phase systems. Additionally, the emergence of microfluidic systems provides an opportunity to miniaturize processes, thereby increasing overall efficiency. The primary objective of this research is to investigate the continuous separation of biomolecules using the polymer-salt aqueous two-phase system. To achieve this goal, the separation of the valsartan drug in the aqueous polymer-salt two-phase system using a circular microchannel was studied. Batch experiments were also performed to compare and improve the performance of the microfluidic system. Firstly, the binodal curve and tielines were extracted through thermodynamic analysis. Then, the synthesis of magnetized iron nanoparticles by surface modification with gums such as xanthan gum, Persian gum, and Arabic gum was discussed. Finally, the separation process was investigated with these nanoparticles, checking parameters such as nanoparticle concentration and pH for both continuous and discontinuous states. In this study, the optimal nanoparticle concentration was determined to be 0.01 wt%, resulting in a partition coefficient of 4.2, 8.3, 7.95 and 8.1 for Valsartan drug in the continuous system with Fe_3 O_4/non-Gum, Fe_3 O_4/Xanthan Gum, Fe_3 O_4/Persian G, Fe_3 O_4/Arabic Gum respectively. In the discontinuous system, the partition coefficients were observed to be 3.6, 5.4, 5.1, and 5.25 for all mentioned nanoparticles, respectively.
