چكيده به لاتين
Hydrogels are a type of three-dimensional network polymer that can be widely swollen in water and are efficient in adsorption with their flexible network. Hydrogels are generally biocompatible and can be synthesized and modified in different ways. Also, the presence of nanoparticles in their structure creates properties such as strength, networking, antibacterial and magnetism. Most of the biomolecules in the biological culture have amphiphilic properties. Including penicillin G, which is one of the most common beta-lactam antibiotics and has hydrophobic properties due to the presence of the beta-lactam ring and positive log p. In this research, the synthesis of magnetic hydrogel based on alginate by sol-gel method with the combination of Fe3O4 magnetic nanoparticles synthesized by co-precipitation method, with alginate precursor and its functionalization with CTAB surfactant by two methods of coating nanoparticles and presence in The structure of the gel is done. The presence of surfactant, due to its bivalent nature in the gel structure, adds hydrophobicity to the hydrogel. The use of affected surfactant improves hydrogel properties such as pore size, water retention, tensile strength and uniformity. The properties and structure of magnetic hydrogels have been evaluated with different analyzes of FT-IR, XRD, SEM and zeta potential. The magnetic hydrogel synthesized by the method of combining surfactant with the gel precursor showed increased pore porosity and relative hydrophobicity. In order to investigate the adsorption of biomolecule on hydrogel synthesized from penicillin G antibiotic, it has been evaluated as a model biomolecule. The effect of 4 factors, the mass ratio of penicillin G to magnetic hydrogel, temperature, time and pH, was investigated using General Factorial Design method at levels 8, 3, 3 and 3 respectively on the amount of antibiotic adsorption on magnetic hydrogel. According to the pKa of penicillin G (2.75), the adsorption rate has increased at pH=2. Adaptation of absorption data with kinetic models revealed that adsorption is multi-stage with physical connections and penetration. Also, adsorption follows the Langmuir isotherm. The maximum adsorption capacity of penicillin G is 126.26 mg/g, which is a good adsorption capacity compared to other adsorbents.
