مليكا شمس نصرتي

Diabetes mellitus as a metabolic and chronic disease is growing, it is still a great threat to human and global health. Hence, its treatment is a big challenge. One of the most important approaches for the treatment of type 2 diabetes is inhibition of the enzyme protein tyrosine phosphatase 1B or (PTP1B). Studies on It is focused on inhibiting this enzyme and finding new heterocyclic compounds with high efficacy and low side effects. In an effort to find new inhibitors for this enzyme, in this thesis a series of new derivatives of 2-oxophenylaminothioquinolines hybridized to benzoimidazole carboxylic acids with the help of nanocatalysts based on natural resins in order to achieve the effects Antidiabetic has been synthesized and the correctness of the synthesis was confirmed using thin layer chromatography and 1H NMR and 13C NMR spectroscopy. In addition, molecular docking studies were performed to eva‎luate the interaction modes of the synthesized compounds in the active site of PTP1B.

بيماري ديابت , آنزيم PTP1B , تركيبات هتروسيكل , كينولين , بنزايميدازول , نانو كاتاليست , داكينگ مولكولي

Diabetes , PTP1B enzyme , Heterocyclic Compounds , Quinolines , Benzoimidazoles , Nanocatalyst , Molecular Docking

Melika Shams Nosrati

Shahrzad Javanshir