چكيده به لاتين
Nowadays, the internalization property of graphene quantum dots and especially the accumulation of these quantum dots contaminated with nitrogen atoms in cancer cells has been confirmed. Also, the use of porphyrin as a photosensitizer and its use in photodynamic therapy and the importance of increasing its applications in the treatment of various types of cancer, especially tumors in deeper tissues, are of great interest. in this research, by functionalizing nitrogen-doped graphene quantum dots (N_GQD) with porphyrin derivatives (TAPP, TCPP), a new combination of photosensitizers was designed, whose HOMO-LUMO band gap was modified and reduced. And by computational and experimental investigation of the hydrogen interaction effect between glutamate present in the cell with them, their use in photodynamic therapy is suggested. First, the structure of 120 atoms of graphene quantum dot and its structure contaminated with nitrogen atom, and then the structures of TAPP and TCPP and further functionalization by N_GQD were drawn and optimized to check the change of their properties. Then their interaction with glutamate molecule was checked to calculate the amount of energy produced to supply exciton energy. Also, through experimental tests, nitrogen-doped graphene quantum dots were synthesized and functionalized with porphyrin derivatives, TAPP and TCPP. Then, during the interaction of these particles in the presence of sodium glutamate, which is an amino acid salt of glutamate, the production of reactive oxygen species was confirmed using the malondialdehyde (MDA) test. To prove the synthesis and investigate the properties of porphyrin derivatives, nitrogen contamination in graphene quantum dots and their functionalization with synthesized porphyrins from the analyzes of ultraviolet-visible absorption spectrophotometer, Fourier transform infrared spectrometer, photoluminescence spectroscopy, scanning electron microscope, contact angle, X-ray diffraction and dynamic light scattering were used.
