اناهيتا بيگي جوزم

eva‎luation of epidermal growth factor receptor-2 (HER2) tumor marker status is important in breast cancer screening, diagnosis, and monitoring. The electrochemical biosensor is a revolutionary method in cancer diagnosis that is used in this research to identify circulating HER2+ tumor cells. The synthesized nanomaterials' electrochemical activity, size, shape, and morphology were analyzed. Metal-organic frameworks based on nickel and carbon quantum dots were made on the surface of graphite electrodes. This made the surface better and improved its electrochemical activity and biocompatibility. This graphite electrode-based biosensor showed excellent performance against HER2-overexpressing SK-BR-3 cancer cells, with a linear dynamic range of 100–2000 cells per ml, and an analytical limit of detection of less than 1 cell/ml. Consequently, the advantages of this highly efficient platform include a wide dynamic range, high specificity, selectivity, reproducibility, and low cost. These characteristics show that the fabricated nano biosensor has a high potential to be used in detecting and monitoring HER2 levels for the care of breast cancer patients and clinical diagnosis.

سرطان پستان، , آنتي بادي HER2، , زيست حسگر الكتروشيميايي، , چارچوب فلز-آلي مبتني بر نيكل(Ni-MOF) , نقاط كوانتومي كربني، , رده سلول SK-BR-3.

Breast cancer، , HER2 antibody، , electrochemical biosensor، , nickel based Metal-Organic Framework(Ni-MOF)، , carbon quantum dots، , SK-BR-3 cells،

Anahita Beigi

Dr. seyed morteza naghib