وحيد كردزاده كرماني

The separation and classification of microparticles are one of the main issues in microfluidic devices. Dielectrophoretic manipulation of particles is known as an advantageous label-free technique for this objective. In this study, we proposed an integrated system utilizing two categories in microfluidics: dielectrophoretic manipulation particles and centrifugal-driven microfluidics, followed by a numerical analysis. In this regard, we assumed a rectangular microchannel with inside unilateral planar electrodes equipped with three equal-sized outlets placed radially on a centrifugal platform (Lab on Disc device) in which microparticles flow. The effect of different coordinate-based parameters, such as radial distance and lateral distance/tilting angle toward radius direction, was calculated on particles’ movement. Additionally, some other operational parameters, including applied voltage, the microchannel width, the number of enabled electrodes, the diameter of particles, and the configuration of electrodes, were analyzed, and the distributions of particles toward the outlets were monitored. It was found that enhanced particle focusing becomes possible at lower rotation speeds and higher electric field values. Additionally, it was found that by appropriately adjusting these affecting parameters, shifting the streams of focused particles between outlets is accurately reachable. Furthermore, the efficiency of the proposed centrifugal-DEP system for the classification of red blood cells/platelets and Live/Dead yeast cells systems was eva‎luated. It was calculated that at the rotation speed of 100 rad/s and 15 V electric field, the classification of RBCs and platelets was accurately accessible. Then, our integrated system was introduced as a novel method for focusing and classifying various microparticles with no need for sheath flows, having the ability to conduct particles at desired routes and focusing.

دي¬الكتروفورز , آزمايشگاه روي ديسك , گريز از مركز , تفكيك/جداسازي , تمركز ذرات

Dielectrophoresis , Electrified Lab on Disc , Micro-particles , Classification , Focusing , Centrifugal microfluidics

Vahid Kordzadeh Kermani

Professor Seyed Nezameddin Ashrafizadeh Dr. Masoud Madadelahi