بابك ميكائيلي كنگرشاهي

Given the preva‎lence of COVID-19, there is a pressing need for immediate and accurate diagnostics. Label-free electrochemical biosensors are emerging as promising and valuable tools for the detection of COVID-19. These biosensors are distinguished by their simplicity, rapid response, sensitivity, and relatively low cost. Accurate COVID-19 biomarkers may be identified through the detection of electrical signals generated from the direct interaction between the target analyte and the recognition element placed on the electrode surface, without the need for labeling or amplification. This can be achieved by bringing the electrode into contact with the target analyte, resulting in signal enhancement. The utilization of gold screen-printed electrodes, also known as Au SPEs, is advantageous when used as electrode material in label-free electrochemical biosensors. This study examines and compares the performance of label-free electrochemical biosensors employing Au SPEs for the detection of COVID-19. The advantages and limitations of each biosensor will also be discussed. These biosensors utilize viral RNA recognition components and depend on various indicators such as viral RNA, viral proteins, and host antibodies. Furthermore, an analysis of the challenges and opportunities that may exist in this burgeoning field has been conducted. This includes enhancing the selectivity and stability of the sensor, optimizing sensor fabrication and design, and validating its efficacy through the use of real clinical samples. It can be argued that label-free electrochemical biosensors utilizing gold screen-printed electrodes (Au SPEs) have significant potential for COVID-19 detection. However, further studies are required to address various challenges, improve their reliability, and expand the range of applications of these technologies.

حسگر الكتروشيميايي , نانوبيوحسگر الكتروشيميايي بدون برچسب , نشانگرهاي زيستي , زيست حسگرهاي الكتروشيميايي نشان‌دار شده

Au SPE , COVID-19 detection , label-free electrochemical nanosensor , biomarkers , labeled electrochemical biosensors

Babak Mikaeeli Kangarshahi

Seyed Morteza Naghib