synthesis and identification of novel organic compounds based on chalcones and eva‎luation of their biological properties

12/16/2025 12:00:00 AM

Chalcones are important structures in organic chemistry that have high reactivity and numerous biological properties due to the presence of α, β-unsaturated ketone structure and have attracted the attention of organic chemists in the field of pharmaceutical synthesis today.This project was carried out with a synthesis approach in the field of medicinal chemistry, and the main goal was to synthesize new organic compounds based on chalcones and investigate their biological properties. In this research, vanillin as a raw material was used and the desired final structure was obtained through several reactions.Considering the importance of click chemistry and the extensive research that has been done on it recently, in the course of this project, the concept of click chemistry was used to place the 1,2,3-triazole ring next to the chalcone structure to use the advantages of both structures. The products obtained from different stages of the work have been identified and analyzed by FT-IR, 1H-NMR and 13C-NMR spectroscopy methods. All the prepared derivatives have been eva‎luated for antifungal properties against Candida albicans and antibacterial properties against Pseudomonas, Staphylococcus aureus and Escherichia coli bacteria. According to the obtained results, all the prepared derivatives show antibacterial properties with a wide range of MIC values. According to the results of MIC and MFC against Candida albicans fungus, the prepared derivatives show significant antifungal properties, and in some derivatives, this property is close to the reference drug fluconazole

چالكون , حلقه تري آزول , شيمي كليك , خاصيت ضد قارچي , خاصيت ضد باكتريايي

Chalcone , Triazole ring , Click chemistry , Antifungal property , Antibacterial property

Khashayar Shadab

Dr. Shahrzad Javanshir