زهراسادات مجتبي پور

Cancer treatment has become one of the important topics in chemistry and nanotechnology research. Nowadays, due to the importance of cancer treatment, which is known as the second cause of death in the world, studies have progressed towards designing systems for the targeted delivery of drugs to the target tissue and reducing its side effects. In this research, for targeted drug delivery to cancer cells, metal-organic framework has been used due to its high biocompatibility and low cytotoxicity. Metal-organic frameworks are synthetic polymer composite materials composed of metal ions or metal clusters and an organic linker that binds the structure together. Porosity is the most important key feature of metal-organic frameworks.In this research, the preparation and determination of the characteristics of drug-carrying nanoparticles, made of metal-organic frameworks coating (with porous structure), along with doxorubicin (as an anti-cancer agent) and in the cellulose substrate and the amino acid arginine penetrating into the cell to increase The anticancer properties of the nanocarrier were well confirmed by a variety of analysis methods. First, the basic biological metal-organic framework was synthesized (Bio-MOF-11) and then the drug doxorubicin was loaded into it. The magnetic cellulose polymer functionalized with guanidine was stretched around the drug-containing nanocarrier, and then in the next step, the properties and structural characteristics of the nanocarrier were eva‎luated. Then, the amount of drug released at different pH was investigated.

چارچوب‌هاي فلز-آلي زيستي، دوكسوروبيسين، آمينواسيد آرژنين، رهايش كنترل شده، سرطان

Metal-organic frameworks, Doxorubicin, Amino acid arginine, Controlled release, Cancer

Zahrasadat mojtabapour

Dr.Ali maleki