الناز احمدسلطاني

Graphene oxide has garnered significant attention due to its unique and remarkable properties, including high specific surface area and the ability to form π orbitals and π-π interactions for enhanced drug loading. This project focuses on incorporating graphene oxide into magnetic hydroxyapatite nanostructures and investigating the drug release from such a targeted drug delivery system. For a precise analysis, four samples were prepared: magnetite/hydroxyapatite, iron and cobalt-doped magnetite/hydroxyapatite, magnetite/hydroxyapatite/graphene oxide, and iron and cobalt-doped magnetite/hydroxyapatite/graphene oxide. Magnetite was synthesized via co-precipitation, while the nanocomposites were synthesized using the hydrothermal method. Various analyses, including XRD, FESEM, SEM, VSM, Raman, FTIR, and MTT assays, were conducted, along with an eva‎luation of the drug release profile of curcumin. According to FESEM and XRD analyses, the crystallite size increased in the presence of graphene. Additionally, the VSM test indicated that the highest saturation magnetization among the four synthesized samples, measured at 22.73 emu/g, was found in the iron and cobalt-doped graphene oxide/magnetite/hydroxyapatite nanocomposite. The MTT analysis further revealed that the concentration of graphene oxide used in the studies, with an IC50 of 74 µg/ml, does not pose a hindrance to biological and drug delivery applications. Finally, the drug release profile, which lasted over 20 days, demonstrated that the nanostructure containing graphene oxide/iron and cobalt-doped hydroxyapatite/magnetite exhibited the highest drug release over a prolonged period.

اكسيدگرافن , هيدروكسي آپاتيت مغناطيسي , هيدروترمال , رهايش دارو

Graphene Oxide , magnetic hydroxyapatite , Hydrothermal , Drug release

Elnaz Ahmad Soltani

Dr. Maryam Tajabadi