چكيده به لاتين
Hyperthermia, as a therapeutic approach in cancer treatment, involves the controlled
application of heat to cancerous tissues to damage tumor cells and enhance their sensitivity to
other treatments such as chemotherapy and radiotherapy. In this study, the results of
numerical simulations of the hyperthermia method using the injection of magnetic
nanoparticles in different tumor tissue models were investigated. For validation purposes, the
simulation results were compared with reference data and previous studies, demonstrating a
favorable agreement with prior research. Furthermore, the effects of parameters such as
nanoparticle size (with diameters of 9, 14, and 19 nanometers) and injection location (center
and peripheral regions of the tumor) on temperature distribution and tissue temperature
increase were analyzed. The results indicated that an increase in nanoparticle diameter led to a
higher volumetric heat power (Qp) and, consequently, an increase in localized tissue
temperature. Additionally, injecting nanoparticles at the tumor center resulted in a higher peak
temperature and a more intense temperature gradient compared to injections in peripheral
regions. In the case of simultaneous dual injection, the synergistic effect of two heat sources
led to an increase in localized temperature and a more uniform heat distribution within the
tissue. The findings of this study highlight that precise control of the physical and geometric
parameters of nanoparticles, along with the optimization of their injection location, plays a
crucial role in improving the efficiency of hyperthermia treatment and reducing damage to
surrounding healthy tissues.
