پريا عربي

Cancer remains one of the greatest challenges of today's world. Despite recent advancements in drug delivery and cancer treatment, biological barriers in the immune system can limit drug absorption. However, drug delivery carriers such as metal-organic frameworks (MOFs), due to their unique properties like porous structure, high surface area, biocompatibility, and biodegradability, help overcome these barriers and facilitate the drug release process. Moreover, stimulus-responsive systems allow for drug release at the right time and place, thereby reducing side effects. In this study, the Fe3O4@NH2-MIL-101(Fe) composite, coated with a chitosan–polyethylene glycol hydrogel, was successfully synthesized and investigated as a carrier for the delivery of the anticancer drug doxorubicin. The identification and synthesis processes of these nanostructures were eva‎luated and confirmed through FT-IR, XRD, VSM, TGA, FESEM, EDX, and EDS elemental mapping analyses. The design of this system demonstrates significant potential in improving the efficiency and enhancing the effectiveness of cancer treatment. The drug loading capacity of doxorubicin, with an efficiency nearing 97%, confirms the high capacity of this platform in drug absorption. Due to the acidic environment of tumors, the pH-sensitive hydrogel coating on this nanostructure triggers drug release under acidic conditions, which not only increases therapeutic efficacy but also helps reduce drug side effects. Doxorubicin release studies were conducted in both tumor-simulated (pH 5) and blood-simulated (pH 7.4) environments, and the results indicated controlled and appropriate drug release.

سرطان , شيمي درماني , دوكسوروبيسين , دارورساني , نانوذرات مغناطيسي اكسيدآهن , هيدروژل كيتوسان-پلي اتيلن گليكول

Cancer , Chemotherapy , Doxorubicin , Drug delivery , Fe3O4 nano particles , Chitosan-Polyethylene glycol hydrogel

Paria Arabi

Mohammad Reza Naimi Jamal