نگين نظيفي

In recent years, the design of smart drug delivery systems aimed at enhancing drug efficacy an‎d reducing side effects has attracted considerable attention. In this study, a nanocomposite based on xanthan gum, guar gum, an‎d halloysite nanotubes was synthesized an‎d investigated as an intelligent carrier for the anticancer drug quercetin. Initially, the natural biopolymers xanthan an‎d guar were combined with halloysite nanotubes at specific ratios to create a nanocomposite matrix with optimized physicochemical properties. Quercetin was then encapsulated into this matrix using a double water/oil/water (W/O/W) nanoemulsion method to achieve efficient loading, controlled release, an‎d improved stability. Techniques such as Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), an‎d dynamic light scattering (DLS) an‎d Zeta potential were employed to characterize the structure, stability, an‎d physicochemical features of the nanocomposite. Drug release studies at different pH levels confirmed targeted drug release in the acidic tumor microenvironment. Moreover, biocompatibility an‎d cytotoxicity assays in cell culture demonstrated the safety of the nanocomposite an‎d its efficacy in delivering the drug to cancer cells. The novelty of this research lies in several aspects: the simultaneous use of two natural biopolymers to improve the mechanical properties an‎d biocompatibility of the system; the incorporation of halloysite nanotubes to enhance the loading capacity an‎d structural stability of the nanocomposite; an‎d the application of a double nanoemulsion method for effective an‎d stable quercetin encapsulation, leading to targeted an‎d controlled drug release in the tumor environment. The findings of this study may pave the way for the development of novel drug delivery systems capable of responding to physiological conditions an‎d reducing the side effects of conventional therapies.

امولسيون دوگانه , گوارگام , زانتان‌گام , دارورساني هوشمند , نانولوله‌هاي هالويزيت

double emulsion , guar gum , xanthan gum , smart drug delivery , halloysite nanotubes

Negin Nazifi

Dr. Ali Maleki