Preparation an‎d characterization of an acid catalyst based on titanium silicalite-1 zeolite an‎d investigating its catalytic performance in the multicomponent synthesis of benzodiazepine derivatives

7/22/2026 12:00:00 AM

In this study, a novel heterogeneous catalyst with dual acidic sites of Lewis an‎d Brønsted nature based on titanium silicate-1 zeolite was synthesized in the form of a hybrid composite, TS-1/UiO-66, an‎d its catalytic performance was investigated in the three-component synthesis of 1,5-benzodiazepine derivatives using dimedone, o-phenylenediamine, an‎d various aromatic aldehydes. The catalyst was prepared through surface functionalization of TS-1 with (3-chloropropyl) trimethoxysilane, followed by grafting of 2-aminoterephthalic acid, an‎d finally in-situ growth of the metal–organic framework UiO-66 on the modified zeolite. This catalytic system offers several advantages, including easy separation, good recyclability, a biocompatible an‎d non-toxic structure, a simple experimental procedure, an‎d reaction efficiency under mild an‎d green conditions.

بنزوديازپين , سنتز چندجزئي , زئوليت تيتانيم سيليكات-1 , چارچوب فلز-آلي UIO-66 , كامپوزيت هيبريدي زئوليت/چارچوب فلز-آلي

Benzodiazepine , Multicomponent synthesis , Titanium silicate-1 zeolite , UIO-66 metal-organic framework , Zeolite/metal-organic framework hybrid composite

Shabnam Ansari

Dr. Ali Maleki