Use of zeolitic imidazolate framework modified with sodium alginate an‎d silver nanoparticles for antibacterial drug release

10/14/2026 12:00:00 AM

Abstract Infectious diseases have had a profound impact on human life throughout history, an‎d their control can save human societies from mortality. In this study, in order to reduce the side effects of antibiotics, tetracycline was loaded with ZIF-8 an‎d then modified with silver nanoparticles to enhance the antibacterial effect. Finally, sodium alginate biopolymer was used to achieve controlled drug release an‎d enhance the biocompatibility of the nanocomposite. The structural characteristics of the synthesized samples were investigated by various methods such as X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, an‎d zeta potential. The drug release characteristics in a simulated in vitro environment were determined using ultraviolet-visible spectroscopy. The results showed that the synthesized carriers have excellent drug loading (99.70%) an‎d pH-sensitive release at the target site. In this way, the drug release from the ZIF-8/TC carrier was 9% in a buffer with pH = 5.50 an‎d 5% in a buffer with pH = 7.40, an‎d the drug release from the ZIF-8/Ag/TC carrier was 51% in a buffer with pH = 5.50 an‎d 23% in a buffer with pH = 7.40, an‎d finally for the ZIF-8/Ag/TC/Alginate nanocomposite, the release was 31% in a buffer with pH = 7.40 an‎d 74% in a buffer with pH = 5.50 within 72 hours. Also, the minimum inhibitory concentration an‎d minimum lethal concentration for Escherichia coli bacteria by the synthesized nanocarrier were 31.25 an‎d 250 μg/ml, respectively, an‎d for Staphylococcus aureus bacteria, 62.5 an‎d 125 μg/ml. These results showed that the modified carrier has a high sensitivity to pH, which allows the release of the antibacterial drug precisely in the bacterial environment that has an acidic pH. As a result, the nanocarriers synthesized in this study can be considered as a new an‎d promising platform in drug delivery for the targeted release of tetracycline. Keywords: Drug delivery, tetracycline, zeolite imidazolate framework, controlled release, pH sensitive

كلمات كليدي: دارورساني، تتراسايكلين، چارچوب ايميدازولات زئوليتي، رهايش كنترل¬شده، حساس به pH

Keywords: Drug delivery, tetracycline, zeolite imidazolate framework, controlled release, pH sensitive

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