Synthesis an‎d Characterization of a Nanocomposite Containing MIL-101(Fe) an‎d Kaolin Clay for the Catalytic Synthesis of Xanthene an‎d Chromene Derivatives

6/18/2026 12:00:00 AM

In this study, a novel heterogeneous catalyst based on an iron metal–organic framework (MIL-101(Fe)) an‎d surface-modified kaolin was designed, synthesized, an‎d characterized. The synthesis involved the functionalization of natural kaolin using chloropropyltrimethoxysilane, followed by grafting with 2-aminoterephthalic acid as an organic linker. Subsequently, MIL-101(Fe) was grown on the modified kaolin substrate, resulting in a stable an‎d catalytically active composite material. The prepared catalyst was thoroughly characterized using FT-IR, XRD, FE-SEM, EDX, BET, BJH, DLS, an‎d TGA analyses, which confirmed its mesoporous structure, uniform morphology, significant surface area, an‎d thermal stability. The catalytic performance of the synthesized material was eva‎luated in the multicomponent green solvent synthesis of xanthene an‎d chromene derivatives, which are bioactive heterocyclic scaffolds. The reactions proceeded efficiently under mild conditions, using a small amount of catalyst, an‎d afforded the desired products in excellent yields (90–95%) within short reaction times . Moreover, the catalyst exhibited good recyclability an‎d could be reused over multiple cycles without significant loss of activity. Overall, the results demonstrate that the developed MIL-101(Fe)/modified-kaolin composite can serve as an efficient, green, an‎d reusable catalyst for the synthesis of pharmaceutically important heterocycles.

چارچوب فلز –آلي , MIL-101(Fe) , كائولينيت اصف اشده , كاتاليزور ناهمگن، , مشتقات زانتن، , مشتقات كرومن , تخلخل , سنتز سبز

Metal-organic framework , MIL-101(Fe) , modified kaolin , heterogeneous catalyst , xanthene derivatives , chromene derivatives , porosity , green synthesis

Maryam Jamili

prof. Ali Maleki