Synthesis an‎d investigation of magnetic an‎d biological properties of iron-based particles coated with bioactive glass

10/21/2026 12:00:00 AM

In this study, zero-valent iron nanoparticles were synthesized by chemical reduction from iron sulfate salt (FeSO₄·7H₂O) using sodium borohydride (NaBH₄) as a reducing agent. In order to prevent iron oxidation an‎d improve biocompatibility, they were protected with a bioactive glass coating, an‎d zinc oxide was added to the glass composition to provide antibacterial properties. Finally, a zero-valent iron nanocomposite coated with bioactive glass an‎d containing zinc oxide was prepared through a co-precipitation process. FE-SEM, EDS, XRD, an‎d FTIR analyses confirmed the presence of iron core, bioactive glass, an‎d zinc oxide. FE-SEM images showed that the zero-valent iron nanocomposites coated with bioactive glass had an average size of 50–80 nm. Magnetometry results showed that glass coating, calcination, an‎d addition of zinc oxide caused a relative decrease in Ms. To assess biocompatibility, a stan‎dard MTT colorimetric test was performed. The results of the MTT test showed that all formulations had good viability in the concentration ranges studied, an‎d the optimal sample selec‎ted was the zero iron sample with a bioactive glass coating at 250 µg/mL. The optimal sample designed under AMF with an intensity of 100 Oe an‎d a frequency of 200 kHz was able to raise the temperature to about 4 °C in ≈330 seconds an‎d showed acceptable thermal performance. According to the results of the antibacterial test, adding 5% zinc oxide to the samples significantly reduced the minimum inhibitory concentration to 500 g/mL, improving the antibacterial properties an‎d increasing the ability to inhibit the growth of microorganisms.

نانوذرات مغناطيسي آهن صفر ظرفيتي، شيشه زيست فعال، اكسيد روي، زيست‌سازگاري، هايپرترميا، احيا شيميايي، هم رسوبي

Zero-valent iron magnetic nanoparticles, bioactive glass, zinc oxide, biocompatibility, hyperthermia, chemical reduction, co-precipitation , Zero-valent iron magnetic nanoparticles, bioactive glass, zinc oxide, biocompatibility, hyperthermia, chemical reduction, co-precipitation

Bahareh Khalilivavdareh

Maryam Tajabadi- Bijan EftekhariYe;ta