Synthesis, characterization an‎d investigation of the antibacterial properties of polydopamine-coated magnetic nanoparticles containing ciprofloxacin

10/22/2026 12:00:00 AM

In recent years, the development of novel drug delivery systems an‎d antibacterial agents with high efficiency an‎d low toxicity has been raised as one of the main challenges in the field of biological nanotechnology. In this study, magnetic iron oxide nanoparticles (Fe₃O₄) were synthesized by co-precipitation method an‎d then coated with a layer of polydopamine (PDA) to improve stability an‎d functionalization capability. In the next step, the drug ciprofloxacin was conjugated with silver nanoparticles (Ag nanoparticles) an‎d immobilized on the surface of Fe₃O₄@PDA to obtain the final nanocomposite Fe₃O₄@PDA/Cipro–Ag. The conjugated ciprofloxacin was attached to silver through the piperazine ring group of the drug an‎d Ag⁺–N coordination bonds, which resulted in high stability of the complex an‎d controlled drug release in environments with different pH. The synthesized nanoparticles were characterized by FT-IR, XRD, VSM, TEM, SEM, DLS an‎d UV–Vis tests. The results showed that the resulting nanoparticles had uniform morphology, average size about 50 nm an‎d acceptable magnetic properties. Investigation of antibacterial activity using agar diffusion method against Escherichia coli an‎d Staphylococcus aureus bacteria showed that the presence of silver an‎d ciprofloxacin together had a significant synergistic effect in increasing the diameter of the zone of inhibition. Overall, the results of this study indicate that the Fe₃O₄@PDA/Cipro–Ag nanocomposite can be used as an effective magnetic drug delivery system an‎d a potent antibacterial agent with controlled release an‎d retrievability in biomedical applications.

ضد باكتري، نانوذره ي نقره، نانوذره مغناطيسي، ضدباكتري سيپروفلوكساسين

Antibacterial, silver nanoparticles, magnetic nanoparticles, antibacterial ciprofloxacin

Zahra Yazdi

Ali Maleki , Seyed Majid Hashemianzadeh