Raman spectroscopy an‎d its applications in medicine

5/12/2027 12:00:00 AM

In this study, the Raman spectra of six pharmaceutical compounds—mefenamic acid, Dephen, acetaminophen, dexamethasone, mosapride, an‎d naproxen—were recorded an‎d analyzed to eva‎luate the capability of Raman spectroscopy as a rapid, non-destructive, an‎d accurate method for drug substance identification. Spectra were recorded in the wavenumber range of 200 to 3300 cm⁻¹. For mefenamic acid, 18 characteristic peaks were identified, with peaks at 1614 an‎d 3302 cm⁻¹ corresponding to benzene ring stretching an‎d N–H stretching, respectively. The Dephen spectrum revealed 24 peaks, with dominant peaks at 1601 (aromatic C=C stretching) an‎d 2919 cm⁻¹ (symmetric CH₃ stretching). Acetaminophen exhibited 21 peaks, with the main characteristic features at 1594 (aromatic C=C stretching) an‎d 3305 cm⁻¹ (amide N–H stretching). The dexamethasone spectrum showed only four peaks, dominated by the peak at 2877 cm⁻¹ (aliphatic C–H stretching). Mosapride also presented four characteristic peaks, with the principal peak at 2880 cm⁻¹ (aliphatic C–H stretching) an‎d a peak at 1692 cm⁻¹ (amide C=O stretching). Naproxen, with 22 peaks, displayed the richest spectrum, with the peak at 1377 cm⁻¹ (intensity 957 units) being the most intense among all compounds. Compounds with extended aromatic rings exhibited the highest number of peaks, whereas steroid compounds showed the fewest peaks. Peaks in the 2800–3000 cm⁻¹ region were present in all six compounds as the most stable common identification markers. The findings demonstrated that Raman spectroscopy can distinguish compounds with similar functional groups based on subtle wavenumber shifts, an‎d peaks below 600 cm⁻¹ provide valuable information regarding polymorphic forms.

طيف‌سنجي رامان , شناسايي دارويي , ، مفناميك اسيد، , استامينوفن

Raman spectroscopy , pharmaceutical identification , mefenamic acid , acetaminophen,

Asma Abd

Dr. Bahreini