6167

6167

بررسي واكنش سيانوسيليل دار كردن تركيبات كربونيل با استفاده از كاتاليزورهاي نمك فتالايميد بخصوص پتاسيم فتالايميد در شرايط بدون حلال

كارشناسي ارشد

شيمي-شيمي آلي

پاييز1387

پاييز1387

دكتر محمد قربان دكامين

دكتر شهرزاد جوانشير

Abstract: Cyanohydrins and their trimethylsilyl ethers are key building blocks for the one-step synthesis of many biologically active compounds. On the other hand, as a consequence of the necessity to minimize the amount of toxic waste and by-products from chemical processes, there is a need to develop new and more environmentally friendly synthetic methods in which fewer toxic substances are used. Nowadays in the development of new syntheses, ecological points of view must also be taken into consideration and apportioned due to importance in the assessment of viability. Many organic solvents are flammable, toxic, and volatile compounds or hazardous air pollutants. Therefore, solvent-free synthesis is highly becoming more popular, especially in industry, because it may be both more environmentally benign and more economically feasible. We have developed a new efficient and mild catalysts which operate under solvent-free conditions (is a very active research effort). Potassium Phethalimide was found to be an effective and easily accessible Lewis basic catalyst for the facile cyanosilylation of carbonyl compounds in high to quantitative yields under solvent-free conditions at room temperature.