چكيده به لاتين
Abstract:
In the present study, 2-pyridinecarbaldehyde thiosemicarbazone compound was synthesized by reflux. The crystal structure of this compound was also determined. This compound was crystallized in Monoclinic crystal system and space group P21 / n and with four molecules in a unit cell. These compounds include three fractions 2-pyridinecarboxaldehyde thiosemicarbazone, a water molecule, and a chlorine ion. 2-pyridinecarboxaldehyde thiosemicarbazone have extensive hydrogen bonds, water molecules and chloride ions across the crystal lattice that this non-covalent interactions, makes 2-pyridine molecules connected to other. This compound was used as ligand for preparing of complexes with Ag (I), Mn (II), Sn (II), Ni (II) and Cu (II) salts. Mn, Ni, Sn complexes have crystalline structure. These Compounds were characterized by UV-VIS, IR, FT-IR, ICP, NMR, atomic absorption and elemental analysis. Then in the microbiology section, the antibacterial properties of synthesized samples with Acinetobacter Baumannii which causes pneumonia were investigated. For investigating of antibacterial activities of the synthesized compounds, MIC (Minimum Inhibitory Concentration) of this bacteria was assessed. The maximum resistance of the bacteria was related to the compound that stoped the growth of bacteria with high concentrations, and the lowest resistance was related to the compound that stoped the growth of bacteria with low concentrations. According to the results, higher concentrations of compounds could stop the growth of bacteria that they have weaker antibacterial activity in vitro.
Keywords: 2-pyridinecarbaldehyde thiosemicarbazone, coordinated complexes, Acinetobacter baumannII, antibacterial ability, MIC
