چكيده به لاتين
Abstract:
Nowadays, there are two major methods of cancer treatment such as invasive and purposeful drug delivery that direct access to tumors and decrease of side effects are the advantage of purposeful drug delivery in comparison with chemical treatment agents. Thus, encapsulation of an anti-cancer drug as temozolomide inside nanotube pharmaceutic carrier can be increased their ability to pass through biological barriers, that result in decreasing drug effects on normal cells and also decreasing of side effects and the consequence of its is the decrease of side effects on the tumor site. Nanotubes exhibit many benefits and this is the major reason that they are used as vehicles for drug delivery the major merit of this study is side effects due to using drugs by patient effectively. The correct concept of encapsulated pharmaceutics molecules behavior inside nanotubes is vital to expanding nanoscale drug delivery vehicles. In this study, investigation of temozolomide drug encapsulation process by a mechanic quantum method in different types of nanotubes considered. primary results indicated SiCNTs excellency among other nanotubes.
The results are indicating that zigzag SiCNT will be establishing vdw-interaction with drug molecule. The decrease in diameter is responsible for the strongest interactions. Also, zigzag nanotube energetically occurring in favorable state and vdw forces play a vital role in the stability of nanotubes.
Some theoretical findings such as binding energies, charge transfer, the density of states plots and total density introduce the nanotubes, typically SiCNT an efficient carrier for delivery of temozolomide drug in nanomedicine domain.
Keywords: nanotube, drug carrier, temozolomide, anti-cancer drug, encapsulation, drug delivery, CNT, BNNT, SCNT
