چكيده به لاتين
Abstract
The Biginelli reaction involves a three-component, one-pot condensation of benzaldehyde, β-keto ester, and urea or thiourea, under strongly acidic conditions. As a result, products of dihydropyrimidin-2(1H)-ones are made. Nowadays, dihydropyrimidin-2(1H)-ones derivatives, have been noticed as one of the most important heterocyclic compounds for the synthesis of a wide range of the pharmacological and biological active compounds. Due to the extensive application of these derivatives in the pharmaceutical industry, the synthesis of these compounds has of great importance and in the recent years, many attempts have been made to provide milder, easier eco-friendly and green chemistry principles methods, use efficient and recyclable catalysts for the synthesis of these compounds. In recent years, attention to graphene oxide (GO) has been increased because of its chemical and mechanical properties. Different chemical modifications have been done on GO that also have widespread applications. One of these applications, the use of modified graphene oxides as a catalyst.
In this work, 1, 3, 5-Tris (2-hydroxyethyl) isocyanurate functionalized graphene oxide (GO-THEIC) nanocatalyst have been reported as mild, efficient, and eco-friendly heterogenous nanocatalyst in the synthesis of dihydropyrimidin-2(1H)-ones derivatives. The significant advantages of this procedure are the reactivity and reusability of the catalyst, low loading of the catalyst, avoiding the use of toxic transition metals, short reaction times, high to excellent yields, easy separation and purification of the products and solvent-free conditions
Keywords: Biginelli reaction, Dihydropyrimidines, Nanocatalyst, Graphene oxide, 1,3,5-Tris (2-hydroxyethyl) isocyanurate (THEIC)
