چكيده به لاتين
Abstract:
Irritable bowel syndrome or IBS is a disorder of intestinal function characterized by chronic pain in the abdominal region, discomfort, bloating and changes in bowel habits, without any other organic cause. Diarrhea or constipation may be the dominant sign that may appear alternately.
One of the most commonly used treatments for the disease is the use of antispasmodic drugs such as mebeverine hydrochloride, which directly affects the smooth muscle of the gastrointestinal tract and relieves spasm without affecting the intestinal motility. The mechanism of action of this drug has a direct relaxing effect on smooth muscle.Studies show that the anti-contractile effect of mebeverine is not limited to a specific system, which results in multiple side effects.
Nowadays, using nanotechnology and nanocarriers knowledge, biodegradation of drugs or biologically active substances can be prevented, as well as reaching target cells, in which the rate of drug release is slowly but continuously.
In this study, mebeverine hydrochloride drug was encapsulated using Niosomic carriers. Niosome were prepared using thin-layer dipping techniques, which include certain ratios of cholesterol, tween 80 and polyethylene glycol.
Then we measured the size of the particle diameter, the amount of encapsulation and drug release. The results showed that drug release from the formulation was slow.
Key Words: Nanotechnology, Niosome, Mebeverine Hydrochloride, Polyethylene Glycol
