چكيده به لاتين
Brain micro-stimulation issue and its application is one of the most important subjects in the field of neurophysiology. The brain stimulation is used in different applications including chronic pain control, tremor control, Parkinson’s disease control, depression control and tele-control of animal and navigation. Also one of the most important problems in the natural disasters, such as floods and earthquakes, is to find victims or injuries. In most situations, due to the high volume of debris, there are no human resources available to search and find people in the event that rat robot can be used.
We study the adaptation effects of stimulation of the MFB region in the rat. So, the surgery and implanting of the electrode in the reward area are used to stimulate the brain to create a reward, and the animal is taught to press the key in the operant conditioning chamber and receive a reward stimulus with each key pressure.
Based on the number of the pressed keys and by varying the stimulating parameters during different stimulation sessions, the effects of adaptation on the stimulation of the MFB over a long time is evaluated. The stimulation parameters for the frequency were changed from 100 to 400 Hz (frequency group), for amplitude from 50 to 170 µA (amplitude group) and for the pulse width from 100 to 2000 µs (pulse width group). Results were obtained by examining frequency, amplitude and pulse width parameters in 5 rats. In the frequency of 250 Hz adaptation occurred. Amplitude hadn’t a significant effect on MFB adaptation and with different pulse widths adaptation occurred between days. This means that the number of keys pressed on the second day was less than the first day.
Keywords: Adaptation, Navigation, Reward Area, Rat, MFB
