چكيده به لاتين
Hyperthermia, in general, means an increase in body temperature above normal levels. High body temperatures typically cause illness, such as fever or heat shock, but controlled temperature increases in some cases are used to treat diseases, especially cancer. Therapy, a process that involves increasing the temperature of the tissues containing the tumor, usually up to 𝟺𝟸°C, with the aim of eliminating cancer cells. This treatment process is usually accompanied by other cancer treatments such as radiation therapy and chemotherapy. The lack of heat distribution in all tumor cells, the inadequate amount of heat produced, and the unwanted thermal treatment of healthy cells, are the most important challenges in current hyperthermia methods. Based on the energy equations in this thesis, the attitude of the imbalance between tissue and blood (two equations) is considered, the verification was first performed in a simple model based on the same research, which indicates that the simulation results are very good. . In the next step, taking into account a sample of the tumor, it employs a schematic of it in modeling and provides an optimization process using the Neldermed method. In optimization, the aim of minimizing is the objective function that simultaneously guarantees the maximum temperature increase inside the tumor and the minimum increase in temperature on the tumor surface. So that the surface temperature of the tumor does not exceed 𝟺𝟹°C and at the same time the maximum temperature of the tumor center is possible. To do this, it defines a function called SAR, which can find the optimum thermal power and radius of injection for any blood flow and porosity. In this study, for example, we examined the velocity of blood flow of 𝟹.𝟺 cm/s and porosity of 𝟶.𝟶𝟶𝟻, and verified the results. According to the results, the optimum thermal power of 𝟹.𝟾𝟼𝟷 MW and the penetration radius of nano-magnetic particles were 𝟶.𝟻𝟽𝟹 mm at steady state.
