چكيده به لاتين
By employing the naturally-originated molecule of creatine, Fe3O4@SiO2@creatine as an environmentally benign magnetic organometallic nanobiocatalyst was successfully prepared via a convenient and green route. Then to acquire an inclusive comprehension of different properties of the catalyst, it was studied by various characterization techniques such as FT‐IR, FE-SEM, TEM, EDX, XRD and VSM analyses. After that, to examine the catalytic activity of this catalyst, it was applied in sequential knoevenagel condensation-Michael addition room temperature reaction of dimedone, malononitrile and different substituted aromatic aldehydes to produce a variety of 2-amino-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives in a single step. Among the multiple outstanding advantages that can be mentioned for this work, some of the most noticeable ones include: affording the products in short reaction times with high yields, operating the reaction at ambient conditions and ease of catalyst separation.
